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[The diet pills that may help you lose weight and are backed by scientific research] Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, by a mean loss of fluid, body fat (adipose tissue), or lean mass (namely bone mineral deposits, muscle, tendon, and other connective tissue). Weight loss can either occur unintentionally because of malnourishment or an underlying disease, or from a conscious effort to improve an actual or perceived overweight or obese state. "Unexplained" weight loss that is not caused by reduction in calorific intake or exercise is called cachexia and may be a symptom of a serious medical condition. Intentional weight loss is commonly referred to as slimming. Weight loss medications are prescribed only as a component of a weight loss program that includes a healthy low-calorie diet and regular physical activity. On average, people on prescription weight loss drugs lose about 5-10% of their orig...